I encourage you to refer to scientific literature to come up with possible answers. Youmay include scheme(s) and/or figure(s) to illustrate a particular point. Please follow therecommended word limits (including the figure captions). Note that for the purposes of any activityin this class, you are prohibited from accessing the information provided by contract cheating sites(examples include Chegg, Course Hero and many others. . Also, note that your answers will bechecked for plagiarism. If found guilty, one will receive zero in this homework, and will bereported to the authorities. (I have attached the two documents that you need, as well as two powerpoints that could be helpful)

Question 1-

In the class, we discussed antiviral compound called acyclovir. Acyclovir is availableas a topical, oral, or IV medication. Oral acyclovir, however, has poor bioavailability (~15% to30%), which necessitates high doses and frequent administration. The development of a prodrug,valacyclovir or valaciclovir, has overcome this limitation, with >50% of the dose being absorbedin adults and achievable plasma levels that are comparable to the IV administration of acyclovir.Summarize the pharmacokinetics of valacyclovir. (400 words; 20 points).

Question 2-

As we discussed in the class, cisplatin is one of the most effective broad-spectrumanticancer drugs. However, the resistance against cisplatin develops rapidly resulting in relapseand therapeutic failure. Summarize the mechanisms with which cancer cells can build resistanceagainst cisplatin (Fig. 1 and Table 1 of the attached paper, Chen and Chang, Int. J. Mol. Sci.,2019). Note: I am looking for a general summary and not precise details of each mechanism (300words; 15 points)

Question 3-

Taxol is one of the most widely used anticancer agents in the world. The antitumoractivity of Taxol results from its ability to promote the assembly and stabilization of microtubules.A better understanding of these interactions is essential for rational drug design and to developnovel and potent chemotherapeutic agents. Using the accompanying manuscript as a guide,Alushin et al., Cell 2018; Figs. 5 and 7, explain the proposed mode of action of Taxol. (400 words;15 points)